Goalkeepers
| # | Player | Club | Age | Caps | Goals |
|---|
| 1 | Sergio Rochet | Internacional | 33 | 35 | 0 |
| 12 | Santiago Mele | Monterrey | 28 | 8 | 0 |
| 23 | Fernando Muslera | Estudiantes | 39 | 134 | 0 |
Defenders
| # | Player | Club | Age | Caps | Goals |
|---|
| 2 | José María GiménezC | Atlético Madrid | 31 | 99 | 8 |
| 3 | Sebastián Cáceres | América | 26 | 24 | 0 |
| 4 | Ronald Araújo | Barcelona | 27 | 27 | 1 |
| 13 | Guillermo Varela | Flamengo | 33 | 28 | 0 |
| 16 | Mathías Olivera | Napoli | 28 | 35 | 2 |
| 17 | Matías Viña | River Plate | 28 | 43 | 1 |
| 24 | Santiago Bueno | Wolverhampton Wanderers | 27 | 8 | 0 |
Midfielders
| # | Player | Club | Age | Caps | Goals |
|---|
| 5 | Manuel Ugarte | Manchester United | 25 | 36 | 1 |
| 6 | Rodrigo Bentancur | Tottenham Hotspur | 28 | 74 | 3 |
| 7 | Nicolás de la Cruz | Flamengo | 29 | 34 | 5 |
| 8 | Federico Valverde | Real Madrid | 27 | 73 | 9 |
| 10 | Giorgian de Arrascaeta | Flamengo | 32 | 60 | 13 |
| 14 | Agustín Canobbio | Fluminense | 27 | 15 | 1 |
| 15 | Emiliano Martínez | Palmeiras | 26 | 10 | 0 |
| 20 | Maximiliano Araújo | Sporting CP | 26 | 28 | 3 |
| 22 | Joaquín Piquerez | Palmeiras | 27 | 19 | 0 |
| 25 | Juan Manuel Sanabria | Real Salt Lake | 26 | 5 | 1 |
| 26 | Rodrigo Zalazar | Braga | 26 | 8 | 2 |
Forwards
| # | Player | Club | Age | Caps | Goals |
|---|
| 9 | Darwin Núñez | Al-Hilal | 26 | 38 | 13 |
| 11 | Facundo Pellistri | Panathinaikos | 24 | 39 | 2 |
| 18 | Brian Rodríguez | América | 26 | 32 | 4 |
| 19 | Rodrigo Aguirre | UANL | 31 | 10 | 3 |
| 21 | Federico Viñas | Oviedo | 27 | 11 | 2 |
URUUruguay